By Silvio Garattini
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Extra info for Advances in Pharmacology and Chemotherapy Volume 14
This finding was also observed in rhesus monkeys (Bruce and Sadun, 1966). Farid et al. (1965) performed a clinical trial with TWSb in 24 NAFTALE KATZ the free-acid form in oil in 4 patients who were treated with 6 mg/kg in 5 intramuscular injections, given twice weekly. m. injections were not unduly painful, no local abscess formation being observed. No radical cures were observed, only a marked reduction in the excretion of S. haematobium eggs. Katz (1965) treated 4 S. mansoni patients using a similar schedule, and 2 of them presented abscess formation whereas the other 2 showed an induration that persisted for 2 to 4 weeks, all patients having complained of intense, severe pain at the site of injection.
Yarinsky repeated such experiments using S. mansoni from the same origin and also from another source than that already used by 42 NAFTALE KATZ Rogers and Bueding (1971). He confirmed the resistance of one strain, but he also reported that, with S . mansoni maintained in the SterlingWinthrop Research Institute, resistance had not been induced (Archer and Yarinsky, 1972). Further studies demonstrated that resistance to hycanthone was maternally transferred, and remained stable for several generations.
Other authors related fatalities after tartar emetic or SAT administration (Walker, 1928; Khalil, 1931; Bittencourt, 1937; Mainzer and Krause, 1940; Alves and Blair, 1946; Dias, 1949; Abdallah and Saif, 1964). In the autopsied cases in Brazil, the pathological picture responsible for death was seen to be intense heart lesion-frngmentntio cordis (Dias, 1949). In the Endemic Diseases Unit in Egypt, tartar emetic has been used for mass treatment for over 40 years. The drug, as a 6% solution, is administered in twelve doses, twice weekly, for a period of 4 weeks.
Advances in Pharmacology and Chemotherapy Volume 14 by Silvio Garattini