By David S. Touretzky (Editor)
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1996. DNA strand breakage, activation of poly(ADP-ribose) synthetase and cellular energy depletion are involved in the cytotoxicity of macrophages and smooth muscle cells exposed to peroxynitrite. Proc. Natl. Acad. Sci. 93, 1753–1758. , 1994. Peroxynitrite releases copper from caeruloplasmin: implications for atherosclerosis. FEBS Lett. 342(1), 49–52. , 1999. Prevention of glucose toxicity in HIT-T15 cells and Zucker fatty rats by antioxidants. Proc. Natl. Acad. Sci. USA 96, 10857–10862. , 1995.
Two of these subunit proteins form the enzyme succinate dehydrogenase, which is a key component of the TCA cycle. This enzyme catalyses the oxidation of succinate to fumarate with the coupled reduction of a covalently bound ﬂavin molecule to form FADH2. The succinate dehydrogenase is anchored to the membrane by the other two proteins (Fig. 3). The ﬂavoprotein subunit of succinate dehydrogenase is intimately linked to an iron–protein subunit of about 270 amino acids which contains prosthetic Fe–S clusters.
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Advances in Neural Information Processing Systems 1 by David S. Touretzky (Editor)