Advances in Cancer Research, Vol. 49 - download pdf or read online

By George Klein (ed.), Sidney Weinhouse (ed.)

ISBN-10: 0120066491

ISBN-13: 9780120066490

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Additional resources for Advances in Cancer Research, Vol. 49

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Thus, it is tantalizing to propose some role of c-fos protein during the monocytic differentiation pathway. Recent results from our laboratory, however, show that c-fos expres- 46 INDER M. VERMA AND W. , 1986). Two lines of evidence advance these inferences: (1)expression of high levels of c-fos by serum or diacyglycerol (DAG) does not commit U-937 cells to differentiate to macrophages and (2) TPA-resistant HL-60 cell lines can be induced to differentiate to macrophages with 1,25-dihydroxyvitamin D3 without eliciting c-fos expression.

C-fos specific transcripts are no longer detected by 120 min. Modified forms of the c-fos protein are also detected during this period. When PC12 cells are treated with dexamethasone, they differentiate to become chromaffin-like cells. , 1986). However, differential neurites upon further addition of fresh NGF showed renewed induction of thefos gene. Thus fos gene expression may be a general anabolic response of the cells to the inducers rather than specific for differentiation. It appears that most inducers of the c-fos gene are also activators of protein kinase C.

Palmieri, S. J . Virol. 58, 134-141. , and Graf, T. (1982). Virology 123, 296-311. , and Graf, T. (1983). EMBO J . 2,2385-2389. , Bartholomew, J. , and Bissell, M. J. (1980). Nature (London)288,720-722. Paterson, B. , and Eldridge, J. D. (1984). Science 224, 1436-1438. Pearson, M. , and Epstein, H. , eds. (1982). ” Cold Spring Harbor Laboratory, Cold Spring Harbor, New York. Pierce, G. , and Wallace, C. (1971). Cancer Res. 31, 127-134. Quinn, L. , and Nameroff, M. (1985). Nature (London)313,692-694.

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Advances in Cancer Research, Vol. 49 by George Klein (ed.), Sidney Weinhouse (ed.)


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